In all honesty, the roles of genetics and how spread about these characters can be would be able to define whether this relationships truly incestuous or not. Let us review what we know in a sort of "family tree" that can distinguish the heritage of Pride Rock's royal family.
Sarabi --- Mufasa Zira --- Scar --- ??
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Simba --- Nala | | Loya
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?? --- Kopa Kiara --- Kovu Nuka Vitani
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Unnamed son
*All dashes ( or --- ) indicate a "relationship" between said characters and from that relationship, an offspring is produced. (There is no confirmation that Scar and Zira were mates, so this is only a speculation and will not be taken literally.)
* All lines going down will show the descent and siblings/those of the same generation on the same line.
* Bold names indicate the main gene or those actually carrying genetics to the Pride Rock royal family (this excludes spouses that marry in.)
From here, we can see that both Loya and the unnamed son (US) both carry the genetics of the royal family but seeing as 2 generations passed since the original gene from Mufasa and Scar's generation has come to pass and mixed with others (US has already become mixed with two other family genes thanks to Nala and his mother/Kopa's mate), to define the term incestuous might be pushing it.
Loya has not been determined properly as we are (or at least, I am not) aware of the mother. I am only presuming that Loya was born in the same generation as Simba and Nala as Scar is already dead before Kiara was even born. This indicates (in canon sense) that Loya is Simba's first cousin. In the next generation, where Nuka through Kiara are, it can be determined that Loya is Nuka/Vitani's half sister but also Kiara/Kopa's second cousin. By the next generation (and when Lopa must be very old), US is already her third cousin.
I am going through canon sense, though, so it might be that I'm totally wrong. But in order to clarify the misunderstandings, Mufasa only has ONE son that is Simba and Simba has TWO children which are Kopa and Kiara. So, there shouldn't be any confusion between Lop and US being in the same generation from that early on.
Scientifically and how nature plays all together, it isn't uncommon for those in family to become mates as it is their ultimate goal to pass down their genes and become dominant within the environment. These are Darwinist views however as survival of the fittest and natural selection often plays out in the animal kingdom but I do not suspect these roleplayers to be thinking in that perspective.
Anyways, it is still true that they are distantly related but either way ,there will be a generation or two separating US and Lopa. Still, this might be a bit extreme if they were to well, reproduce, but that's for them to worry about.
Hope this helps!
--SoaringAway